No, 2023 ACR/EULAR APS classification criteria are intended for clinical research and have lower sensitivity for detecting APS than the 2006 revised Sapporo classification criteria: 84% vs 99%. In addition, the ACR/EULAR criteria have ELISA-based cutoffs, but many laboratories do not use ELISA-based tests for cardiolipin and ß2-glycoprotein I antibody testing. Therefore, evaluating results using the 99th percentile cutoff (revised Sapporo criteria) yields higher sensitivity compared to the 2023 ACR/EULAR APS classification criteria guidelines. In addition, persistent non-criteria antibodies (eg, phosphatidylserine or prothrombin antibodies) may provide alternative laboratory evidence for APS if criteria antibodies are negative.