Skip to main content
Quest Diagnostics

FISH, Prenatal Screen

Test code: 14604

This assay screens for numerical abnormalities of chromosomes 13, 18, 21, X, and Y: trisomy 13, trisomy 18, trisomy 21 (Down syndrome), and sex chromosome abnormalities such as Turner syndrome, Klinefelter syndrome, and triploidy.

The following chromosome disorders are not screened:

  • Aneuploidy of chromosomes other than 13, 18, 21, X, and Y
  • Structural chromosome abnormalities
  • Low-level mosaicism

The American College of Medical Genetics recommends that irreversible therapeutic action should not be taken based on the results of FISH analysis alone. After a positive FISH result, clinical decision-making should be based on additional information, either a confirmatory chromosome analysis or consistent clinical information.1

Reference

1. Test and technology transfer committee, American College of Medical Genetics. Technical and clinical assessment of fluorescence in situ hybridization: An ACMG/ASHG position statement. Genet Med. 2000;2(6):356-61.


This FAQ is provided for informational purposes only and is not intended as medical advice. A physician’s test selection and interpretation, diagnosis, and patient management decisions should be based on the physician’s education, clinical expertise, and assessment of the patient.


Document FAQS.59 Version: 1

Version 1: Effective 12/12/2023 to present

Version 0: Effective 05/30/2012 to 12/12/2023

Related content

Publication
Prenatal Diagnosis of Diencephalic-Mesencephalic Junction Dysplasia: Fetal Magnetic Resonance Imaging Phenotypes, Genetic Diagnoses, and Outcomes
Test FAQ
Chromosomal Microarray Prenatal ClariSure Oligo SNP
Test FAQ
QNatal Advanced
Audio Podcast
A Commitment to Women’s Health
On-Demand Webinar
The Role of Adverse Pregnancy Outcomes in Heart Disease Prevention

Our company

Quest® is the brand name used for services offered by Quest Diagnostics Incorporated and its affiliated companies. Quest Diagnostics Incorporated and certain affiliates are CLIA certified laboratories that provide HIPAA covered services.  Other affiliates operated under the Quest® brand, such as Quest Consumer Inc., do not provide HIPAA covered services. 

 

Quest®, Quest Diagnostics®, any associated logos, and all associated Quest Diagnostics registered or unregistered trademarks are the property of Quest Diagnostics. All third-party marks—® and ™—are the property of their respective owners. © 2024 Quest Diagnostics Incorporated. All rights reserved. Image content features models and is intended for illustrative purposes only.